The National Down Syndrome Society is the leading human rights organization for all individuals with Down syndrome.

The mission of the National Down Syndrome Congress is to provide information, advocacy and support concerning all aspects of life for individuals with Down syndrome.

The mission of the Global Down Syndrome Foundation is to significantly improve the lives of people with Down syndrome through research, medical care, education and advocacy.

The mission of the Research Down Syndrome LuMind Foundation is to stimulate biomedical research that will accelerate the development of treatments to significantly improve cognition, including memory, learning and speech, for individuals with Down syndrome so they participate more successfully in school, lead more active and independent lives, and avoid the early onset of Alzheimer's Disease.

DS-Connect™: The Down Syndrome Registry, is the new Down syndrome registry hosted by the National Institutes of Health (NIH) and the Down Syndrome Consortium. The goals of DS-Connect are to gain a better understanding of Down syndrome, to learn more about the health issues associated with Down syndrome, to develop new treatments for Down syndrome and to improve care for people with Down syndrome.